Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1933 1
1938 1
1946 2
1948 1
1953 1
1954 1
1955 5
1956 5
1957 15
1958 11
1959 26
1960 13
1961 30
1962 122
1963 391
1964 528
1965 487
1966 657
1967 773
1968 810
1969 927
1970 879
1971 968
1972 1046
1973 1144
1974 1122
1975 986
1976 881
1977 820
1978 749
1979 711
1980 698
1981 600
1982 666
1983 698
1984 729
1985 741
1986 755
1987 656
1988 631
1989 690
1990 769
1991 738
1992 724
1993 723
1994 786
1995 736
1996 749
1997 724
1998 684
1999 724
2000 787
2001 750
2002 715
2003 698
2004 723
2005 853
2006 882
2007 906
2008 895
2009 901
2010 938
2011 1028
2012 1102
2013 1151
2014 1074
2015 1056
2016 1025
2017 923
2018 883
2019 807
2020 896
2021 836
2022 506
2023 386
2024 142

Text availability

Article attribute

Article type

Publication date

Search Results

46,703 results

Results by year

Filters applied: . Clear all
Page 1
Targeted lactate dehydrogenase genes silencing in probiotic lactic acid bacteria: A possible paradigm shift in colorectal cancer treatment?
Macharia JM, Kaposztas Z, Varjas T, Budán F, Zand A, Bodnar I, Bence RL. Macharia JM, et al. Biomed Pharmacother. 2023 Apr;160:114371. doi: 10.1016/j.biopha.2023.114371. Epub 2023 Feb 7. Biomed Pharmacother. 2023. PMID: 36758316 Free article. Review.
The objective of this study was therefore to determine the detrimental effects of LAB-derived lactic acid in the colonic mucosa in colorectal cancer management. ...Our research suggests that targeting LAB metabolic pathways is capable of suppressing tumor growth and …
The objective of this study was therefore to determine the detrimental effects of LAB-derived lactic acid in the colonic mucos …
Targeting lactate metabolism for cancer therapeutics.
Doherty JR, Cleveland JL. Doherty JR, et al. J Clin Invest. 2013 Sep;123(9):3685-92. doi: 10.1172/JCI69741. Epub 2013 Sep 3. J Clin Invest. 2013. PMID: 23999443 Free PMC article. Review.
LDHA promotes osteoblast differentiation through histone lactylation.
Nian F, Qian Y, Xu F, Yang M, Wang H, Zhang Z. Nian F, et al. Biochem Biophys Res Commun. 2022 Jul 30;615:31-35. doi: 10.1016/j.bbrc.2022.05.028. Epub 2022 May 13. Biochem Biophys Res Commun. 2022. PMID: 35605402
As a newly discovered protein posttranslational modification, lactate-derived histone lactylation has been found to play important roles in gene regulation and have profound effects on diverse biological processes. Here, we found that the expression of lactate dehydrogenase …
As a newly discovered protein posttranslational modification, lactate-derived histone lactylation has been found to play important roles in …
Role of LDH in tumor glycolysis: Regulation of LDHA by small molecules for cancer therapeutics.
Sharma D, Singh M, Rani R. Sharma D, et al. Semin Cancer Biol. 2022 Dec;87:184-195. doi: 10.1016/j.semcancer.2022.11.007. Epub 2022 Nov 9. Semin Cancer Biol. 2022. PMID: 36371026 Review.
Lactate dehydrogenase (LDH) is one of the crucial enzymes in aerobic glycolysis, catalyzing the last step of glycolysis, i.e. the conversion of pyruvate to lactate. ...Several genetic and phenotypic studies established the potential role of lactate dehydrogenase A ( …
Lactate dehydrogenase (LDH) is one of the crucial enzymes in aerobic glycolysis, catalyzing the last step of glycolysis, i.e. the con …
Construction of lactic acid overproducing Clostridium thermocellum through enhancement of lactate dehydrogenase expression.
Mazzoli R, Olson DG, Lynd LR. Mazzoli R, et al. Enzyme Microb Technol. 2020 Nov;141:109645. doi: 10.1016/j.enzmictec.2020.109645. Epub 2020 Aug 12. Enzyme Microb Technol. 2020. PMID: 33051021
Rapid expansion of global market of lactic acid (LA) has prompted research towards cheaper and more eco-friendly strategies for its production. ...It is known that eliminating allosteric regulation can also increase lactic acid production in C. thermoc …
Rapid expansion of global market of lactic acid (LA) has prompted research towards cheaper and more eco-friendly strategies fo …
Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice.
Yao S, Xu MD, Wang Y, Zhao ST, Wang J, Chen GF, Chen WB, Liu J, Huang GB, Sun WJ, Zhang YY, Hou HL, Li L, Sun XD. Yao S, et al. Nat Commun. 2023 Feb 9;14(1):729. doi: 10.1038/s41467-023-36209-5. Nat Commun. 2023. PMID: 36759610 Free PMC article.
Through an unbiased proteomic screen coupled with biochemical verifications, we show that the levels of glycolysis and lactate dehydrogenase A (LDHA), a glycolytic enzyme that catalyzes L-lactate production, are reduced in the dorsomedial prefrontal cortex (d …
Through an unbiased proteomic screen coupled with biochemical verifications, we show that the levels of glycolysis and lactate dehydrogen …
Major role of lactate dehydrogenase D-LDH1 for the synthesis of lactic acid in Fructobacillus tropaeoli CRL 2034.
Bleckwedel J, Mohamed F, Mozzi F, Raya RR. Bleckwedel J, et al. Appl Microbiol Biotechnol. 2020 Sep;104(17):7409-7426. doi: 10.1007/s00253-020-10776-9. Epub 2020 Jul 14. Appl Microbiol Biotechnol. 2020. PMID: 32666186
The enzymes D- and L-lactate dehydrogenase are involved in the reduction of pyruvate to D(+)- and L(-)-lactate, respectively. ...Key Points F. tropaeoli CRL 2034 harbors three ldh genes in its genome. ldh1 and ldh2 encode D-lactate dehydrogen …
The enzymes D- and L-lactate dehydrogenase are involved in the reduction of pyruvate to D(+)- and L(-)-lactat …
Unappreciated Role of LDHA and LDHB to Control Apoptosis and Autophagy in Tumor Cells.
Urbańska K, Orzechowski A. Urbańska K, et al. Int J Mol Sci. 2019 Apr 27;20(9):2085. doi: 10.3390/ijms20092085. Int J Mol Sci. 2019. PMID: 31035592 Free PMC article. Review.
Among the enzymes mediating this plasticity through bidirectional conversion of pyruvate and lactate, the lactate dehydrogenase A (LDHA) and lactate dehydrogenase B (LDHB), are indicated. ...
Among the enzymes mediating this plasticity through bidirectional conversion of pyruvate and lactate, the lactate dehydrogenase A (LD …
Lactic Acid Production from a Whole Slurry of Acid-Pretreated Spent Coffee Grounds by Engineered Saccharomyces cerevisiae.
Kim JW, Jang JH, Yeo HJ, Seol J, Kim SR, Jung YH. Kim JW, et al. Appl Biochem Biotechnol. 2019 Sep;189(1):206-216. doi: 10.1007/s12010-019-03000-6. Epub 2019 Apr 10. Appl Biochem Biotechnol. 2019. PMID: 30969397
Valorization of the SCG has been increasingly focused following considerable attention in coffee consumption. Lactic acid bacteria fermentation is the primary source of generation of lactic acid, a monomer of polylactic acid that has various ind …
Valorization of the SCG has been increasingly focused following considerable attention in coffee consumption. Lactic acid bact …
Lactic acid production by Rhizopus oryzae transformants with modified lactate dehydrogenase activity.
Skory CD. Skory CD. Appl Microbiol Biotechnol. 2004 Apr;64(2):237-42. doi: 10.1007/s00253-003-1480-7. Epub 2003 Nov 18. Appl Microbiol Biotechnol. 2004. PMID: 14624317
The goal of this work was to increase lactate dehydrogenase (LDH) activity, so lactic acid fermentation could more effectively compete for available pyruvate. ...Since lactic acid fermentation competes with ethanol and fumaric acid produc …
The goal of this work was to increase lactate dehydrogenase (LDH) activity, so lactic acid fermentation could more effe …
46,703 results
You have reached the last available page of results. Please see the User Guide for more information.